Septerna Inc· SEPN

🇺🇸 US · SmallBroad USNASDAQ

Healthcare Biotechnology Website

Price: $39.50
Day: +2.76%
Mkt Cap: $1.78B
52W Range: $14.52 – $51.10
Volume: 241.5K
Beta: 2.29

D35D Framework

Valuation Analysis

Intrinsic-value engines paired with peer-anchored multiples.

Valuation: 2.0 / 5 (Above estimate); at $39.50 the price is 29% above the blended estimate of $28
Estimates: sector peers $28 (158 companies)

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Valuation Assessment

SEPN Valuation Summary

How sector peers and the stock's own history value it (no intrinsic model available for this stock)

Overall valuation

2.0/5

Above estimate

Market only · blended estimate

$28-28.7%

2 readings sit beyond $43 and show as arrows past the end of the axis. Hover or tap one for its value.

Based on the market evidence from peers and the stock's own history, the price is 29% above the market estimate.Last updated September 18, 2026.

Valuation Multiples

Per-metric breakdown of how SEPN is priced relative to its sector peers, its own 10-year history, and analyst forward estimates.

Valuation context: This company is currently unprofitable with negative EBITDA. P/E and EV/EBITDA aren't meaningful; focus on EV/FCF and FCF Yield in the primary grid, plus revenue multiples (P/S, EV/Sales) in the expanded section.

What sector peers imply

Value if it traded at the sector-median multiple

What its own history implies

Value if it traded at its own 10-year median multiple

How the Multiples lens works

Five primary multiples surface the headline call; five additional multiples sit one click deeper for context.

Valuation multiples compare a company's market price to its financial fundamentals. The primary grid covers both the equity perspective (P/E, PEG, FCF Yield) and the enterprise value perspective (EV/EBITDA, EV/FCF) so you see how the market prices the company two ways simultaneously.

Price-based multiples use market cap and reflect what equity investors pay. EV-based multiples include debt and are better for comparing companies with different capital structures. The expanded section below adds P/B, P/S, P/FCF, EV/EBIT, and EV/Sales for additional perspective.

Learn more about the 5D valuation methodology

Septerna Inc· SEPN

Valuation Analysis

Valuation Multiples

Additional valuation multiples5 more metrics: P/B Ratio, P/S Ratio, P/FCF, EV/EBIT, EV/Sales

How implied prices are calculated

Primary multiples primer

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Valuation Analysis

Valuation Multiples

Additional valuation multiples5 more metrics: P/B Ratio, P/S Ratio, P/FCF, EV/EBIT, EV/Sales

How implied prices are calculated

Primary multiples primer