Septerna Inc· SEPN

🇺🇸 US · SmallBroad USNASDAQ

Healthcare Biotechnology Website

Price: $39.50
Day: +2.76%
Mkt Cap: $1.78B
52W Range: $14.52 – $51.10
Volume: 241.5K
Beta: 2.29

D25D FrameworkTTM Data

Peer Comparison

Performance vs sector and industry peers across 40 metrics.

Peer Comparison: 2.2 / 5 (Weak) against 158 sector peers in United States · Small Cap · Healthcare
Pillars: strongest Leverage & Coverage 3.7, weakest Margin Efficiency 1.0 (9 of 10 ranked)
Ranks: ROIC 44th percentile, operating margin 10th percentile

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Septerna Inc

SEPN|Healthcare|Biotechnology

Comparing against 158 sector peers in United States · Small Cap · Healthcare

Peer Comparison

Dimension 2 of 5

Revenue Growth

N/A

Operating Margin

10%ile

-44.0%

ROIC

44%ile

-8.9%

FCF Yield

81%ile

5.9%

Growth & Cash Flow Quality

Percentile ranking across profitability growth and cash generation

EBITDA Growth

-53.9%

EBIT Growth

-53.3%

Net Income Growth

-72.3%

OCF Growth

-230.2%

FCF Growth

-226.6%

Income Quality

-4.37

Returns on Capital (TTM)

ROE(-6.3%)

58%ile

Average

PoorWeakAdequateStrongExceptional

ROCE(-8.9%)

43%ile

Average

PoorWeakAdequateStrongExceptional

ROA(-4.3%)

56%ile

Average

PoorWeakAdequateStrongExceptional

ROIC(-8.9%)

44%ile

Average

PoorWeakAdequateStrongExceptional

Profit Margins (TTM)

Gross Margin(N/A)

N/A

PoorWeakAdequateStrongExceptional

EBITDA Margin(-40.2%)

10%ile

Bottom 20%

PoorWeakAdequateStrongExceptional

Operating Margin(-44.0%)

10%ile

Bottom 20%

PoorWeakAdequateStrongExceptional

Net Margin(-24.5%)

17%ile

Bottom 20%

PoorWeakAdequateStrongExceptional

Leverage & Coverage (TTM)

Debt/Equity

63%ile

0.06

Debt/Capital

62%ile

0.06

Net Debt/EBITDA

44%ile

1.56

Interest Coverage

N/A

Liquidity (TTM)

Current Ratio

48%ile

4.99

Quick Ratio

50%ile

4.99

Cash Ratio

43%ile

1.07

WC Turnover

44%ile

0.33

Operational Efficiency (TTM)

Asset Turnover

24%ile

0.17

DSO

43%ile

58.8

Days Inventory

72%ile

0.00

Cash Conv. Cycle

N/A

TTM: Trailing Twelve Months · EBITDA: Earnings Before Interest, Taxes, Depreciation & Amortization · EBIT: Earnings Before Interest & Taxes · ROA: Return on Assets · ROIC: Return on Invested Capital · ROCE: Return on Capital Employed · ROE: Return on Equity · OCF: Operating Cash Flow · FCF: Free Cash Flow · DSO: Days Sales Outstanding · WC: Working Capital

See the complete picture

The full 5D Framework: Business Quality · Peer Comparison · Valuation · Analyst Sentiment · Smart Money

Explore SEPN on stockoscope.com→

Generated September 19, 2026

For educational purposes only. Not financial advice. Data may be delayed or incomplete.

158 sector peers (United States · Small Cap · Healthcare)

Relative Quality

SEPN Relative Quality Score

Ranked against 158 sector peers in United States · Small Cap · Healthcare

Relative Quality

2.2/5

Weak

vs 158 sector peers

Peer Rankings (9 of 10 available)

Relative Quality Score of 2.22/5 (Weak) based on percentile rankings against 158 sector peers in United States · Small Cap · Healthcare. Each pillar shows a 1-5 score plus the cohort percentile (e.g. 95p = top 5%); higher percentiles indicate stronger relative performance.Last updated September 18, 2026.

Top-Line and Profit Growth

How does the company's growth rate compare to peers?

No data for Revenue Growth is available for SEPN, so peer comparison is hidden for this metric. Try another metric.

Margin Efficiency

Does the company maintain better profit margins than peers?

No data for Gross Margin is available for SEPN, so peer comparison is hidden for this metric. Try another metric.

Operational Efficiency

Is the company more operationally efficient than competitors?

Asset Turnover

24th percentile, Weak

Value: 0.17
Percentile: 24%
Score: 2/5

PoorWeakAdequateStrongExceptional

Analysis

SEPN has a ttm asset turnover of 0.17 and ranks at the 24th percentile vs United States · Healthcare sector peers. Below average financial performance.

Returns Overview

Does the company generate better returns on capital than peers?

ROA

56th percentile, Adequate

Value: -4.28%
Percentile: 56%
Score: 3/5

PoorWeakAdequateStrongExceptional

Analysis

SEPN has a ttm roa of -4.28% and ranks at the 56th percentile vs United States · Healthcare sector peers. Adequate financial performance.

Cash Flow Quality

How does the company's cash generation compare to peers?

Operating Cash Flow Growth

3rd percentile, Poor

Value: -230.23%
Percentile: 3%
Score: 1/5

PoorWeakAdequateStrongExceptional

Analysis

SEPN has a ttm operating cash flow growth of -230.23% and ranks at the 3rd percentile vs United States · Healthcare sector peers. Poor financial performance.

Liquidity and Working Capital

Does the company maintain better liquidity positions than competitors?

Cash Ratio

43rd percentile, Adequate

Value: 1.07
Percentile: 43%
Score: 3/5

PoorWeakAdequateStrongExceptional

Analysis

SEPN has a ttm cash ratio of 1.07 and ranks at the 43rd percentile vs United States · Healthcare sector peers. Adequate financial performance.

Leverage and Coverage

Is the company's debt burden more manageable than peers?

Debt to Capital

62nd percentile, Strong

Value: 0.06
Percentile: 62%
Score: 4/5

PoorWeakAdequateStrongExceptional

Analysis

SEPN has a ttm debt-to-capital of 0.06 and ranks at the 62nd percentile vs United States · Healthcare sector peers. Strong financial performance.

Valuation Multiples

Is the company's stock valuation attractive relative to peers?

P / E Ratio

Insufficient peer data

Value: -73.15
Percentile: n/a
Score: n/a

PoorWeakAdequateStrongExceptional

Analysis

Not enough peer data to rank SEPN for ttm p/e ratio in this cohort.

Dividend and Shareholder Yield

Does the company deliver superior income to shareholders compared to peers?

No data for Dividend Yield is available for SEPN, so peer comparison is hidden for this metric. Try another metric.

Peer companies

The 160 companies SEPN is compared against across its sector and industry cohorts.

Septerna Inc· SEPN

Peer Comparison

Top-Line and Profit Growth

Per-Share Fundamentals

Margin Efficiency

Operational Efficiency

Returns Overview

Cash Flow Quality

Liquidity and Working Capital

Leverage and Coverage

Valuation Multiples

Dividend and Shareholder Yield

Peer companies

Search stocks

Peer Comparison

Top-Line and Profit Growth

Per-Share Fundamentals

Margin Efficiency

Operational Efficiency

Returns Overview

Cash Flow Quality

Liquidity and Working Capital

Leverage and Coverage

Valuation Multiples

Dividend and Shareholder Yield

Peer companies